IBANDRONIC ACID-D3
ibandronic acid
CAS: 114084-78-5
Molecular Formula: C9H23NO7P2
IBANDRONIC ACID-D3 - Names and Identifiers
| Name | ibandronic acid |
| Synonyms | Ibandronic Ibandronate Ibadronic Acid Ibandronic acid ibandronic acid Ibandronate acid IBANDRONIC ACID-D3 1-Hydroxy-3-(methylpentylamino)propylidene bisphosphonic acid {1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphnic Acid [1-Hydroxy-3-(methyl-d3-pentylamino)propylidene]bisphosphnic Acid P,P'-[1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic Acid {1-hydroxy-3-[methyl(pentyl)amino]propane-1,1-diyl}bis(phosphonic acid) |
| CAS | 114084-78-5 |
| InChI | InChI=1/C9H23NO7P2/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17) |
IBANDRONIC ACID-D3 - Physico-chemical Properties
| Molecular Formula | C9H23NO7P2 |
| Molar Mass | 319.23 |
| Density | 1.449±0.06 g/cm3(Predicted) |
| Melting Point | 113-115°C |
| Boling Point | 587.8±60.0 °C(Predicted) |
| Flash Point | 309.3°C |
| Solubility | Aqueous Base (Slightly), Methanol (Slightly), Water (Slightly) |
| Vapor Presure | 2.88E-16mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 1.60±0.10(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Hygroscopic |
| Refractive Index | 1.537 |
IBANDRONIC ACID-D3 - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| pharmacology and toxicology | ibandronic acid is a bisphosphonate compound that acts specifically on bone tissue, the specific selective effect on bone is due to the high affinity of bisphosphonates for inorganic substances in bone. Bisphosphonates work by inhibiting the activity of osteoclasts, but the exact mechanism of action is unclear. In vivo, ibandronic acid prevents bone destruction due to loss of gonadal function, retinoids, tumors or tumor extracts. Ibandronic acid was shown to inhibit endogenous bone reabsorption by pharmacokinetic studies and experiments on Ca45 to observe the release of radiolabeled tetracycline from bone. When the dose of ibandronic acid is much higher than the pharmacologically effective dose, there is no effect on the osteogenic process. Studies have shown that ibandronic acid inhibits tumor-induced osteolysis, especially the clinical treatment of tumor hypercalcemia is characterized by a decrease in blood calcium level and urinary calcium excretion. |
| Application | ibandronic acid, a clear colorless liquid. Adapted to the treatment of tumors caused by pathological (abnormal) elevated blood calcium (hypercalcemia). Children, pregnant women and lactating women disabled. Severe renal insufficiency is contraindicated. |
| biological activity | Ibandronic acid is a highly potent nitrogen-containing bisphosphonate that acts on osteoporosis. |
| Use | calcium regulator |
Last Update：2024-04-10 22:29:15
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